Naukar Rakh Le Sanware Bhajan Song. 61 songs of 61 videos.Theophylline and theophylline esters in aqueous solution: solubility, hydrodynamic diameter, and stability over time.
Theophylline and theophylline in the form of esters have recently become the focus of commercial development in the field of medicinal and personal care. The aim of this work was to evaluate the stability of theophylline and theophylline in the form of its ester at different storage conditions (as a function of pH). The assessment was based on the change in the hydrodynamic diameter of the particles, which was measured by photon correlation spectroscopy (PCS) and on the stability of the theophylline and theophylline ester solutions over time, measured with liquid chromatography (LC). Particles with a hydrodynamic diameter of 0.05-0.9 microm were found in the samples. The particles are in the form of molecular clusters and could be aggregates of single particles or particles containing a lipophilic core in the center surrounded by a hydrophilic surface. The particles became smaller and the size distribution became narrower at the higher pH (7-9). The LC method revealed a decrease of the concentration of theophylline at higher pH (10-11). Moreover, it was found that, as a result of the hydrolysis, the concentrations of theophylline ester in solution decrease over time (five times faster than the concentration of theophylline), while the hydrodynamic diameter of the particles did not change significantly during the measurements. This observation may indicate that the particles may contain the theophylline ester core.Elizabeth Wells
Elizabeth Wells, (1609-1670) was an English Quaker and co-founder of the Religious Society of Friends (Quakers) in the English Midlands.
Elizabeth was born in 1609 in Stalybridge, Cheshire, England. She was the daughter of a Quaker farmer and an active Catholic. Her father opposed the dissolution of the Monasteries and the Corn Laws and went to jail for refusing to pay tithes and taxes to the Crown. Elizabeth joined her family in the conversion to the Quakers.
Elizabeth was a prolific writer and sometime speaker and missionary for Quakers. She is well remembered for her book, A Brief Outline of the Whole State of the 0b46394aab